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FLASH GENE

Symbol

MPPED2

contributors: mct - updated : 08-06-2021

HGNC name	metallophosphoesterase domain containing 2
HGNC id	1180

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to murine 2700082O15 Rik
	homolog to drosophila CG2789

intraspecies

homolog to C22orf1

Homologene

FAMILY

UPF0046 family

CATEGORY

SUBCELLULAR LOCALIZATION

basic FUNCTION

serine/threonine phosphatase

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

text	neurogenesis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   is a critical event in breast carcinogenesis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	biomarker for thyroid cancer exhibiting differences in the correlation coefficients between benign and malignant samples that indicate its discriminatory power
Therapy target
	System Type Disorder Pubmed cancer brain glioma/neuroblstoma MPPED2 expression impairs neuroblastoma tumorigenesis

ANIMAL & CELL MODELS