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FLASH GENE

Symbol

MPPED2

contributors: mct - updated : 08-06-2021

HGNC name	metallophosphoesterase domain containing 2
HGNC id	1180

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	202.92 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

Map

see CD59

regionally located

located in the WAGR region btween PAX6 and FSHB

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001377956 7 - 6022 NP_001364885 - 277 - 2019 30846004 NM_001145399 7 - 6061 NP_001138871 - 277 - 2019 30846004 NM_001584 7 - 2562 NP_001575 - 294 - 2019 30846004 NM_001377952 7 - 2614 NP_001364881 - 294 - 2019 30846004 NM_001377953 7 - 2647 NP_001364882 - 294 - 2019 30846004 NM_001377954 7 - 2325 NP_001364883 - 294 - 2019 30846004 NM_001377955 7 - 2307 NP_001364884 - 294 - 2019 30846004

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	brain predominantly

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to murine 2700082O15 Rik
	homolog to drosophila CG2789

intraspecies

homolog to C22orf1

Homologene

FAMILY

UPF0046 family

CATEGORY

SUBCELLULAR LOCALIZATION

basic FUNCTION

serine/threonine phosphatase

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

text	neurogenesis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   is a critical event in breast carcinogenesis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	biomarker for thyroid cancer exhibiting differences in the correlation coefficients between benign and malignant samples that indicate its discriminatory power
Therapy target
	System Type Disorder Pubmed cancer brain glioma/neuroblstoma MPPED2 expression impairs neuroblastoma tumorigenesis

ANIMAL & CELL MODELS