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FLASH GENE
Symbol ADAMTS14 contributors: npt/ - updated : 06-02-2006
HGNC name ADAM metallopeptidase with thrombospondin type 1 motif, 14
HGNC id 14899
PROTEIN
PHYSICAL PROPERTIES Amphiphilic
STRUCTURE
motifs/domains
  • a propeptide region
  • a metalloproteinase domain
  • a disintegrin-like domain
  • a cysteine-rich domain
  • a thrombospondin type 1 (TS) motif
    • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to Drosophila kst
    homolog to murine Adamts 14
    homolog to C.elegans sma-1
    intraspecies homolog to ADAMTS3
    homolog to ADAMTS2
    Homologene
    FAMILY
  • ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family
    • CATEGORY adhesion , enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text associated with the extracellular matrix
    basic FUNCTION
  • having aminoprocollagen activity
  • active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS