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FLASH GENE
Symbol ADAMTS14 contributors: npt/ - updated : 06-02-2006
HGNC name ADAM metallopeptidase with thrombospondin type 1 motif, 14
HGNC id 14899
Location 10q21.3      Physical location : 72.432.558 - 72.522.193
Synonym name
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 14
  • metalloprotease-disintegrin protease
  • Synonym symbol(s) ADAM-TS14, FLJ32820
    EC.number 3.4.24.-
    DNA
    TYPE functioning gene
    STRUCTURE 89.64 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text using two different promoters
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing initiation site 3721 133.9 1223 - Colige
    - splicing initiation site 3730 134.2 1226 - Colige
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   lowly
    Respiratorylung   lowly
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text lung and kidney, placenta (lowly)
    PROTEIN
    PHYSICAL PROPERTIES Amphiphilic
    STRUCTURE
    motifs/domains
  • a propeptide region
  • a metalloproteinase domain
  • a disintegrin-like domain
  • a cysteine-rich domain
  • a thrombospondin type 1 (TS) motif
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to Drosophila kst
    homolog to murine Adamts 14
    homolog to C.elegans sma-1
    intraspecies homolog to ADAMTS3
    homolog to ADAMTS2
    Homologene
    FAMILY
  • ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family
  • CATEGORY adhesion , enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text associated with the extracellular matrix
    basic FUNCTION
  • having aminoprocollagen activity
  • active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS