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FLASH GENE
Symbol SNUPN contributors: mct - updated : 16-12-2015
HGNC name snuportin 1
HGNC id 14245
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal importin beta-binding domain (IBB), for binding to, and import by, importin beta, and both need to be returned to the cytoplasm after having delivered their cargoes to the nucleus (Paraskeva 1999), essential for TMG cap-mediated snRNP import
  • C terminal m3G-cgp binding region (TMG)
    • conjugated RiboP
    HOMOLOGY
    interspecies homolog to murine Rnut1
    ortholog to drosophila CG42303/snup
    Homologene
    FAMILY
  • snurportin family
    • CATEGORY adaptor , RNA associated , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • nuclear import adapter for cytoplasmically assembled, m(3)G-capped spliceosomal U snRNPs (small nuclear ribonucleoproteins) (Monecke 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complex SMM1/KPNB1
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SMN
  • KPNB1
  • binds XPO1 in a bipartite manner by means of an amino-terminal LR-NES (leucine-rich nuclear export signal) and its nucleotide-binding domain (Dong 2009)
  • exported by XPO1, the receptor for leucine-rich nuclear export signals (NESs) (Paraskeva 1999)
  • two additional interaction sites between TPR and SNUPN, suggesting a possible role for TPR import into the nucleus
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS