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FLASH GENE
Symbol ADAM33 contributors: npt/ - updated : 21-10-2006
HGNC name ADAM metallopeptidase domain 33
HGNC id 15478
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • signal sequence
  • ADAM cystein-rich domain
  • one EGF-like domain
  • one disintegrin domain
  • metalloproteinase domain
  • the typical zinc-binding consensus sequence
  • one transmembane domain
  • a cytoplasmic domain
    • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to C.elegans F54D8.3
    homolog to xenopus Adam13
    intraspecies homolog to ADAM13, ADAM19
    Homologene
    FAMILY
  • peptidase family M12B
  • ADAM (a disintegrin and metalloprotease domain) family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text membrane protein type 1
    basic FUNCTION
  • involved in chronic obstructive pulmonary disease
  • plays an important role in airway remodeling and bronchial hyper-responsiveness
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to asthma and bronchial hyperresponsiveness
  • to aspirin- and non-steroidal anti-inflammatory drugs -intolerant asthma
    • Variant & Polymorphism SNP , other
  • polymorphism accelerating the proliferation of smooth muscle cells leading to bronchial hyperreactivity
  • SNP contributing to the development of aspirin- and non-steroidal anti-inflammatory drugs -intolerant asthma
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS