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FLASH GENE

Symbol

ADAM33

contributors: npt/ - updated : 21-10-2006

HGNC name	ADAM metallopeptidase domain 33
HGNC id	15478

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	14.12 kb     22 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - splicing 3594 - 813 - Yoshinaka, Wang variant 2 - splicing 3510 - 787 - Yoshinaka, Wang

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain           nerve cranial nerve     highly Reproductive female system uterus     highly Respiratory lung alveolar duct     highly   respiratory tract trachea     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular smooth

cells

System Cell Pubmed Species Stage Rna symbol   digestive

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	signal sequence
	ADAM cystein-rich domain
	one EGF-like domain
	one disintegrin domain
	metalloproteinase domain
	the typical zinc-binding consensus sequence
	one transmembane domain
	a cytoplasmic domain

conjugated

MetalloP

HOMOLOGY

interspecies	homolog to C.elegans F54D8.3
	homolog to xenopus Adam13

intraspecies

homolog to ADAM13, ADAM19

Homologene

FAMILY	peptidase family M12B
	ADAM (a disintegrin and metalloprotease domain) family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
text	membrane protein type 1

basic FUNCTION	involved in chronic obstructive pulmonary disease
	plays an important role in airway remodeling and bronchial hyper-responsiveness

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to asthma and bronchial hyperresponsiveness to aspirin- and non-steroidal anti-inflammatory drugs -intolerant asthma

Variant & Polymorphism SNP , other	polymorphism accelerating the proliferation of smooth muscle cells leading to bronchial hyperreactivity
	SNP contributing to the development of aspirin- and non-steroidal anti-inflammatory drugs -intolerant asthma

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS