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FLASH GENE
Symbol ADAM33 contributors: npt/ - updated : 21-10-2006
HGNC name ADAM metallopeptidase domain 33
HGNC id 15478
Location 20p13      Physical location : 3.648.620 - 3.662.738
Synonym name
  • a disintegrin and metalloproteinase domain 33
  • disintegrin and reprolysin metalloproteinase family protein
  • chromosome 20 open reading frame 153
    • Synonym symbol(s) AD33, FLJ35308, FLJ36751, MGC149823, MGC71889, C20orf153, DKFZp434K0521, dJ964F7.1
    EC.number 3.4.24.-
    DNA
    TYPE functioning gene
    STRUCTURE 14.12 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 3594 - 813 - Yoshinaka, Wang
    - splicing 3510 - 787 - Yoshinaka, Wang
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
     nervecranial nerve  highly
    Reproductivefemale systemuterus  highly
    Respiratorylungalveolar duct  highly
     respiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmooth   
    cells
    SystemCellPubmedSpeciesStageRna symbol
     digestive
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • signal sequence
  • ADAM cystein-rich domain
  • one EGF-like domain
  • one disintegrin domain
  • metalloproteinase domain
  • the typical zinc-binding consensus sequence
  • one transmembane domain
  • a cytoplasmic domain
    • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to C.elegans F54D8.3
    homolog to xenopus Adam13
    intraspecies homolog to ADAM13, ADAM19
    Homologene
    FAMILY
  • peptidase family M12B
  • ADAM (a disintegrin and metalloprotease domain) family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text membrane protein type 1
    basic FUNCTION
  • involved in chronic obstructive pulmonary disease
  • plays an important role in airway remodeling and bronchial hyper-responsiveness
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to asthma and bronchial hyperresponsiveness
  • to aspirin- and non-steroidal anti-inflammatory drugs -intolerant asthma
    • Variant & Polymorphism SNP , other
  • polymorphism accelerating the proliferation of smooth muscle cells leading to bronchial hyperreactivity
  • SNP contributing to the development of aspirin- and non-steroidal anti-inflammatory drugs -intolerant asthma
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS