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FLASH GENE
Symbol ADAMTS16 contributors: mct - updated : 18-11-2009
HGNC name ADAM metallopeptidase with thrombospondin type 1 motif, 16
HGNC id 17108
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one metalloproteinase domain
  • one disintegrin-like domain
  • five thrombospondin type 1 (TS) motif
  • a peptidase M12B domain
  • a PLAC domain
    • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to C.elegans R166.5
    intraspecies homolog to ADAMTS18
    Homologene
    FAMILY
  • ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular matrix
    basic FUNCTION
  • active protease that have potentially a physiological role in ovarian follicles, at least during the pre-ovulatory phase
  • involved in blood pressure regulation
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the synovium and cartilage of osteoarthritis
    Susceptibility to variation of systolic blood pressure
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS