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FLASH GENE

Symbol

ADAMTS16

contributors: mct - updated : 18-11-2009

HGNC name	ADAM metallopeptidase with thrombospondin type 1 motif, 16
HGNC id	17108

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5p15.32      Physical location : 5.140.442 - 5.320.411
Synonym name	a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 16
Synonym symbol(s)	ADAMTS16s, FLJ16731, KIAA2029, ADAM-TS 162
EC.number	3.4.24.-

DNA

TYPE	functioning gene
STRUCTURE	179.97 kb     23 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_139056 23 - 4974 NP_620687 134 1224 - 2009 19423552

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node         Homo sapiens Reproductive female system ovary     highly Homo sapiens Urinary kidney       predominantly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one metalloproteinase domain
	one disintegrin-like domain
	five thrombospondin type 1 (TS) motif
	a peptidase M12B domain
	a PLAC domain

conjugated

MetalloP

HOMOLOGY

interspecies

homolog to C.elegans R166.5

intraspecies

homolog to ADAMTS18

Homologene

FAMILY

ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
text	extracellular matrix

basic FUNCTION	active protease that have potentially a physiological role in ovarian follicles, at least during the pre-ovulatory phase
	involved in blood pressure regulation

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in the synovium and cartilage of osteoarthritis

Susceptibility

to variation of systolic blood pressure

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS