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FLASH GENE

Symbol

ADAMTS15

contributors: npt/ - updated : 26-09-2002

HGNC name	ADAM metallopeptidase with thrombospondin type 1 motif, 15
HGNC id	16305

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	24.85 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed ADAMTS15 8 - 2853 103 950 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial absorptive excretory

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	ADAM cystein-rich domain
	thrombospondin type 1 domain

conjugated

MetalloP

HOMOLOGY

interspecies

homolog to C.elegans R10H10.1

Homologene

FAMILY	ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family
	reprolysin family zinc metalloprotease

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

basic FUNCTION

involved in intestinal epithelial cells wound-healing processes and may have important pathophysiological roles in intestinal cells

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS