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FLASH GENE
Symbol GTPBP4 contributors: mct - updated : 18-08-2011
HGNC name GTP binding protein 4
HGNC id 21535
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • elongation factor TU
    • HOMOLOGY
    interspecies homolog to yeast S.cerivisiae NOG1
    Homologene
    FAMILY
  • GTP1/OBG family
  • NOG subfamily
    • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • tumor suppressor that regulates and requires merlin to suppress cell proliferation
  • nucleolar protein involved in 60S ribosome biogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP
    protein
  • interacts with the neurofibromatosis 2 protein (NF2)
  • interaction with merlin impairing the turnover of merlin, yet merlin does not affect the GTPase nor GTP-binding activity of GTPBP4
  • interacting with TP53
  • DDX51 is a ribosome synthesis factor and an interacting partner of GTPBP4
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer, correlated with reduced patient survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS