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FLASH GENE
Symbol GTPBP4 contributors: mct - updated : 18-08-2011
HGNC name GTP binding protein 4
HGNC id 21535
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Endocrineadrenal gland   highly
endocrinebraindiencephalonpituitary lowly
Reproductivemale systemtestis  highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Urinaryepithelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • elongation factor TU
    • HOMOLOGY
    interspecies homolog to yeast S.cerivisiae NOG1
    Homologene
    FAMILY
  • GTP1/OBG family
  • NOG subfamily
    • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • tumor suppressor that regulates and requires merlin to suppress cell proliferation
  • nucleolar protein involved in 60S ribosome biogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP
    protein
  • interacts with the neurofibromatosis 2 protein (NF2)
  • interaction with merlin impairing the turnover of merlin, yet merlin does not affect the GTPase nor GTP-binding activity of GTPBP4
  • interacting with TP53
  • DDX51 is a ribosome synthesis factor and an interacting partner of GTPBP4
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer, correlated with reduced patient survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS