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FLASH GENE
Symbol GTPBP4 contributors: mct - updated : 18-08-2011
HGNC name GTP binding protein 4
HGNC id 21535
Location 10p15.3      Physical location : 1.034.348 - 1.063.704
Synonym name
  • G protein-binding protein CRFG
  • G protein binding protein, chronic renal failure gene
  • GTP-binding protein NGB
  • Synonym symbol(s) NGB,CRFG, FLJ10690, FLJ10686, NOG1, FLJ39774
    DNA
    TYPE functioning gene
    STRUCTURE 29.36 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    DMBT1 10q25.3-q26.1 deleted in malignant brain tumors 1 KIAA0514 10q11.22 KIAA0514 gene product LOC387730 10 similar to Glutamate dehydrogenase 1, mitochondrial precursor (GDH) LOC390027 10 similar to germ cell specific Y-box binding protein; contrin LOC390020 10 similar to sperm associated AWN protein BS69 10p15-p14 adenovirus 5 E1A binding protein KIAA0934 10p15.3 adenovirus 5 E1A binding protein KIAA0217 10p15.3 KIAA0217 protein LOC143034 10p15.3 hypothetical LOC143034 GTPBP4 10p15-p14 GTP binding protein 4 IDI2 10p15.3 isopentenyl-diphosphate delta isomerase 2 HT009 10p15.3 uncharacterized hypothalamus protein HT009 IDI1 10p15.3 isopentenyl-diphosphate delta isomerase KIAA0982 10p15.3 isopentenyl-diphosphate delta isomerase ADARB2 10p15 adenosine deaminase, RNA-specific, B2 (RED1 homolog rat)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 2537 74 634 - 2007 17210637
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Endocrineadrenal gland   highly
    endocrinebraindiencephalonpituitary lowly
    Reproductivemale systemtestis  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinaryepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • elongation factor TU
  • HOMOLOGY
    interspecies homolog to yeast S.cerivisiae NOG1
    Homologene
    FAMILY
  • GTP1/OBG family
  • NOG subfamily
  • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • tumor suppressor that regulates and requires merlin to suppress cell proliferation
  • nucleolar protein involved in 60S ribosome biogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP
    protein
  • interacts with the neurofibromatosis 2 protein (NF2)
  • interaction with merlin impairing the turnover of merlin, yet merlin does not affect the GTPase nor GTP-binding activity of GTPBP4
  • interacting with TP53
  • DDX51 is a ribosome synthesis factor and an interacting partner of GTPBP4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer, correlated with reduced patient survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS