basic FUNCTION
| playing a role in cellular signaling (mitotic inhibitor) |
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methylating specific arginine residues in the small nuclear ribonucleoproteins Sm D1 and Sm D3 |
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involved in the control of transcription and proliferation |
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may play a role in cytokine-activated transduction pathways |
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negatively regulating cyclin E1 promoter activity and cellular proliferation |
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may regulate the SUPT5H transcriptional elongation properties |
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methylating histone H2A/H4 Arg-3 during germ cell development |
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involved in an early stage of U7 snRNP assembly and hence may have a second snRNP assembly function unrelated to sDMA modification |
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involved in cyclin E repression |
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required for skeletal muscle differentiation at the early stages of myogenesis |
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effector recruited to SNAI1 through an interaction with JUB that functions to repress the SNAI1 target gene, CDH1 |
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effector of SNAI1-dependent gene repression |
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playing a role in developmental globin gene silencing |
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may play a developmentally specific role in regulating gene expression at the gamma-globin locus |
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distinct functions of the nuclear and the WDR77/PRMT5 complexes in the developing fetal testis and in the oncogenesis of testicular tumors |
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required for Sm protein sDMA modification |
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binds to the non-LIM region of JUB and is translocated into the nucleus in a SNAI1- and JUB-dependent manner |
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required for early-gene expression but dispensable for late-gene expression of myogenesis |
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major pro-survival factor regulating eIF4E expression and TP53 translation |
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participates in the assembly of the transcriptional repressor complex on different eukaryotic promoters |
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involved in the formation of the complex that negatively regulates aldolase A gene transcription during the cell cycle |
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links the circadian clock to the control of alternative splicing in plants |
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PRMT1 and PRMT5 methylate Arg-296 within ASH2L |
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catalyzes monomethylation and symmetric dimethylation of arginine residues |
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role of PRMT5 in glial cell differentiation and PRMT5 is linked to epigenetic changes during oligodendrocyte differentiation |
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plays a role in gene silencing during oligodendrocyte differentiation |
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plays critical roles in cellular processes as diverse as receptor signaling and gene expression |
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probably promotes tumor growth by stimulating cell proliferation and by participating in the construction of a tumor-favorable microenvironment via HIF1 activation |
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critical coactivator component in HOXA9-containing transcription complex |
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is a master regulator of splicing in mammals |
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WDR77 can transform cells independent of AR and ESR, and PRMT5 has partial contribution to that process |
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likely WDR77 and PRMT5 simultaneously engage the protein substrate, orienting its targeted arginine to the catalytic site |
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is a potential vulnerability across multiple cancer lineages augmented by a common "passenger" genomic alteration |