| basic FUNCTION
| antagonizing cell death and regulating the cell cycle |
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playing an essential role in the cell death mechanism of injured motoneurons in collaboration with XIAP, BIRC4BP, BIRC2 |
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playing a critical role in the maintenance of a normal innate immune inflammatory response |
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recruits two UBE2B molecules, through the RING domains (specific contacts between UBE2B and RING are required for activity) |
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through its E3 ubiquitin ligase activities, promote proteasomal degradation of NIK (NF-kappaB-inducing kinase) and regulate the non-canonical NF-kappaB pathway |
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promote cancer cell survival by functioning as E3 ubiquitin ligases that maintain constitutive ubiquitination of the RIPK1 adaptor protein |
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BIRC2, BIRC3, and XIAP act cooperatively via nonredundant pathways to regulate genotoxic stress-induced nuclear factor-kappaB activation |
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likely suppress apoptosis, at least in part, by facilitating the ubiquitination and turnover of active effector caspases in cells |
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a key regulator of programmed cell death and the NFKB pathway |
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BIRC2, BIRC3, and MAP3K7 protect cells from TNF-induced necrosis by preventing RIPK1/RIPK3-dependent ROS production |
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XIAP, BIRC2, BIRC3 are important regulators of inflammatory processes in endothelial cells |
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roles for TNFSF12, BIRC3, and noncanonical NFKB1 signaling in the regulation of myoblast fusion and highlight a role for cytokine signaling during adult skeletal myogenesis |
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NAIP is abundantly expressed in M2 macrophages, while BIRC2 and BIRC3 show an inverse pattern of expression in polarized macrophages, with elevated expression levels of BIRC2 in M2 and BIRC3 preferentially expressed in M1 |
