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FLASH GENE
Symbol ESAM contributors: mct - updated : 10-05-2023
HGNC name endothelial cell adhesion molecule
HGNC id 17474
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • V-type and C2-type immunoglobulin domain
  • one hydrophic signal sequence
  • one transmembrane region
  • one cytoplasmic domain
    • HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin receptor family
    • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    plasma membrane,junction,adherens
    text colocalizing with markers of tight junction and restricted at the most apical tip of lateral cell surfaces
    basic FUNCTION
  • playing a role in cell-cell interactions that is critical for vascular development or function
  • plays essential roles in stress-induced hematopoiesis
  • ESAM expression in hematopoietic progenitors is essential for erythroid recovery after a bone marrow (BM) injury
  • ESAM had important roles in developing definitive hematopoiesis
  • essential role for endothelial barrier integrity in a tissue-specific way
  • regulates inflammatory cell adhesion and transmigration and promotes angiogenesis
  • ESAM plays a mechanistic role in proper myocardial vascularization and the maintenance of Left ventricular diastolic function under basal and hemodynamic stress conditions
  • encodes a TJ (tight junction) protein related to JAM proteins involved in the formation and maintenance of the BBB
  • endothelial cell-selective adhesion molecule, which mediates homophilic interactions between endothelial cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ESAM interacts with endoglin
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DDIDE
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in some primary acute myeloid leukemia cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a useful marker for studying both human hematopoietic stem cells and leukemia cells
  • candidate circulating biomarker to predict the risk of progression to kidney failure
    • Therapy target
    ANIMAL & CELL MODELS
  • mice with endothelial cell-selective adhesion molecule deficiency develop coronary microvascular rarefaction and left ventricle diastolic dysfunction