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FLASH GENE

Symbol

PPM1D

contributors: mct/pgu - updated : 09-05-2017

HGNC name	protein phosphatase 1D magnesium-dependent, delta isoform
HGNC id	9277

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	Wip1-/- mice display immunodeficiency, abnormal lymphoid histopathology in thymus and spleen, defects in B- and T-cell differentiation, as well as susceptibility to viral infection
	Wip1-deficient mice exhibit a significant reduction of B-cell numbers in the bone marrow, peripheral blood, and spleen