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FLASH GENE
Symbol SLC22A10 contributors: mct - updated : 07-01-2021
HGNC name solute carrier family 22 (organic anion/cation transporter), member 10
HGNC id 18057
Location 11q12.3      Physical location : 63.057.429 - 63.079.237
Synonym symbol(s) OAT5, hOAT5
DNA
TYPE functioning gene
STRUCTURE 21.82 kb     10 Exon(s)
regulatory sequence Promoter
Binding site
text structure
  • two HNF-1A binding elements in the proximal promoter, located at nucleotides -68/-56 and -173/-160 (
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2591 - 541 - 2001 11327718
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver     Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve transmembrane domains (12TM),with cytoplasmic N and C termini . one nucleotide (ATP/GTP) binding site motif
    • HOMOLOGY
    Homologene
    FAMILY solute carrier family 22, organic anion
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • anion exchangers that transport small hydrophilic anions and diuretics, antibiotics, nonsteroidal anti-inflammatory drugs, antiviral nucleoside analogs, and antitumor drugs across membrane barriers of epithelia of diverse organs
  • OATS4 (SLC22A9, SLC22A10, SLC2A24, and SLC22A25) members are specifically associated with conjugated sex hormones
  • SLC22A10 and SLC22A25 are only linked to conjugated sex hormones, making them relatively mono-specific transporters
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • transactivated by hepatocyte nuclear factor-1 (HNF-1A)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS