Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SYTL4 contributors: mct - updated : 14-02-2014
HGNC name synaptotagmin-like 4
HGNC id 15588
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal Slp homology domain
  • made of two conserved region SHD/SH2 linked together
  • two protein KC conserved region to (CALCB) C2 at the C terminus
    • HOMOLOGY
    interspecies homolog to murine Sytl4
    Homologene
    FAMILY
  • synaptotagmin C2 domain containing protein family
  • Rab27a effector family proteins
    • CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • synaptic vesicles
  • endogenous platelet SYTL4 and RAB8A colocalized in the center of activated platelets, where granule secretion takes place
    • basic FUNCTION
  • regulated exocytosis in endocrine tissues
  • modulates amylase release from parotid acinar cells through interaction with syntaxin-2/3 on the apical plasma membrane
  • control potentially insulin secretion through interaction with STX1A and/or STXBP2
  • crucial component of the docking machinery of insulin-containing vesicles to the plasma membrane
  • STXBP1 and SYTL4 collaborate in the docking of insulin granules to the plasma membrane in an initial fusion-incompetent state, with STXBP1 subsequently playing a positive role in a later stage of insulin granule exocytosis
  • SYTL4 and RAB8A enhance dense granule release and the SYTL4 effect is dependent on RAB8A binding
  • SYTL4 and SYTL1 differentially regulate the exocytosis of either stably or minimally docked granules, respectively
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text vesicular transport
    PATHWAY
    metabolism
    signaling
  • activation of the SREBF1/SYTL4 pathway is a potential mechanism for impaired insulin secretion in diabetes, contributing to beta cell lipotoxicity
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding RAB27A/B (GTP bound form)
  • SYTL4 and EXPH5 are RAB27A and RAB27B effectors
  • binds to syntaxin-2 and syntaxin-3 as well as STX1A, and likely mediates granule docking through interactions with those multiple syntaxins on the plasma membrane
  • SYTL4 and RAB8A are expressed and interact in human platelets, and might be involved in dense granule release
  • RAB27A-SYTL4 complex on WPB (Weibel-Palade body) promotes exocytosis through an interaction with STXBP1, thereby controlling the release of vaso-active substances in the vasculature
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS