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FLASH GENE

Symbol

MN1

contributors: mct/npt - updated : 14-01-2020

HGNC name	meningioma (disrupted in balanced translocation) 1
HGNC id	7180

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MN1 , DDDFD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       MN1TEL, a leukemia-related fusion protein containing parts of the MN1 and TEL (ETV6) genes (Meester-Smoor 2007) tumoral     --over   in certain types of human acute myeloid leukemia (Grosveld 2007) tumoral     --other   aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia (Kuang 2008) tumoral     --over   contribute to poor colorectal cancer (CRC) prognosis constitutional     --over   induces proliferation and represses myeloid differentiation of primitive hematopoietic cells

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	can serve as a novel potential biomarker in predicting the prognosis of colorectal cancer (CRC) patients
Therapy target

ANIMAL & CELL MODELS