Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MN1 contributors: mct/npt - updated : 14-01-2020
HGNC name meningioma (disrupted in balanced translocation) 1
HGNC id 7180
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal nuclear localization signal,
  • proline-rich sequences,
  • two polyglutamine stretches
  • multiple transcription activating domains
  • C-terminal region of MN1 is required for degradation through the ubiquitin-proteasome pathway
    • HOMOLOGY
    interspecies homolog to C.elegans F13D12.4
    Homologene
    FAMILY
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may be playing a role in tumor suppression
  • activates the transcription activity of the moloney sarcoma virus long terminal repeat, indicating that this protein itself may act as a transcription factor (Van Wely 2003)
  • may stimulate RAR/RXR-mediated transcription through interaction with EP300 (Van Wely 2003)
  • transcriptional co-activator and oncoprotein which activates transcription of the IGFBP5 promoter through a CACCC-rich consensus sequence (Meester-Smoor 2007)
  • MN1 plays a critical role in human craniofacial and brain development
  • MN1 plays a role in transcriptional regulation through interaction with the DNA-binding transcription factors PBX1 and PKNOX1
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MN1 participates in transcriptional regulation of target genes through interaction with the transcription factors PBX1, PKNOX1, and ZBTB24
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MN1 , DDDFD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    MN1TEL, a leukemia-related fusion protein containing parts of the MN1 and TEL (ETV6) genes (Meester-Smoor 2007)
    tumoral     --over  
    in certain types of human acute myeloid leukemia (Grosveld 2007)
    tumoral     --other  
    aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia (Kuang 2008)
    tumoral     --over  
    contribute to poor colorectal cancer (CRC) prognosis
    constitutional     --over  
    induces proliferation and represses myeloid differentiation of primitive hematopoietic cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • can serve as a novel potential biomarker in predicting the prognosis of colorectal cancer (CRC) patients
    • Therapy target
    ANIMAL & CELL MODELS