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FLASH GENE
Symbol PRKCZ contributors: mct/npt/pgu - updated : 09-07-2014
HGNC name protein kinase C, zeta
HGNC id 9412
Location 1p36.33      Physical location : 1.981.908 - 2.116.832
Synonym name
  • atypical protein kinase C
  • PKC zeta
    • Synonym symbol(s) PKC2, PKCZ
    EC.number 2.7.11.1, 2.7.11.13
    DNA
    TYPE functioning gene
    STRUCTURE 134.93 kb     18 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 splicing 2359 67 592 - 2009 19201988
    15 splicing 2147 46 409 - 2009 19201988
  • differing in the 5' UTR and having multiple coding region differences compared to variant 1
  • translation initiation from a downstream ATG caused by these differences
  • variants 2 and 3 encode the same isoform (2)
    • 18 splicing 2044 46 409 - 2009 19201988
  • differing in the 5' UTR and having multiple coding region differences compared to variant 1
  • translation initiation from a downstream ATG caused by these differences
  • variants 2 and 3 encode the same isoform (2)
    		•
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon moderately
    Endocrineneuroendocrinepituitary  highly
     parathyroid   highly
    Lymphoid/Immunethymus   moderately
    Nervousbrain   highly
    Reproductivefemale systemplacenta  predominantly
     female systembreastmammary gland moderately
     male systemtestis  highly
    Respiratoryrespiratory tractlarynx  moderately
    Visualeyeretina  moderately
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualbipolar cell
    Visualrod photoreceptor
    cell lineage
    cell lines
    fluid/secretion highly in lymph
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an octicosapeptide, Ca2+ binding motif
  • a phorbol-ester/DAG-type zinc finger domain (C1)
  • a catalytic domain
    • mono polymer complex
    HOMOLOGY
    interspecies homolog to rattus Prkcz (96.1pc)
    homolog to murine Prkcz (95.6pc)
    homolog to Drosophila aPKC (62pc)
    Homologene
    FAMILY
  • protein kinase superfamily
  • AGC Ser/Thr protein kinase family
  • PKC subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
        intracellular
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • endogenous stabilizer of microtubule cytoskeleton EGF protection and of intestinal barrier function against oxidative injury
  • acting as a serine-threonine kinase
  • mediating insulin effects on glucose transport in cultured preadipocyte-derived human adipocytes
  • serving as the receptor for phorbol esters, a class of tumor promoters
  • playing a central role in epithelial cell polarization
  • involved in the control of pre-mRNA splicing and partcularly controling DNA topoisomerase-dependent
  • plays an important role in supporting cell survival
  • may function as a physiological BAX kinase to directly phosphorylate and interact with BAX, leading to sequestration of BAX in cytoplasm and abrogation of the proapoptotic function of BAX
  • caspase-2 pre-mRNA splicing
  • regulator of cardiomyocyte myofilament protein phosphorylation
  • might play an important role during the cardiac hypertrophic process
  • regulates epidermal growth factor-induced chemotaxis of breast cancer cells
  • required for macrophage migration and is required for CSF1-induced chemotaxis of macrophages
  • expression of PRKCZ and PRKCI or both are dispensable for primitive and adult hematopoietic stem cell fate determination in steady-state and stress hematopoiesis
  • NTRK2 and PRKCZ, two critical regulators of synaptic plasticity, facilitate DLG4 targeting to synapses
  • is a critical metabolic tumor suppressor in cancer (PMId: 23374352)
  • acts as a metabolic tumor suppressor by inhibiting PHGDH expression and activity
  • direct or indirect role for PRKCZ in the biochemical response to nutrient stress activated by the lack of glucose in cells that require this nutrient for survival and growth
  • is a critical player in the important metabolic pathway for cancer
    • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    intracellular signaling cascade
    a component
  • forming a complex with PARD3, PARD6A or PARD6B or PARD6G and CDC42 or RAC1
  • forming a complex with PARD3, PARD6A, CDC42, ALS2CR19
  • forming a ternary complex with SQSTM1 and KCNAB2
  • forming a ternary complex composed of SQSTM1 and PAWR
  • forming another ternary complex with SQSTM1 and GABRR3
  • forming a complex with SQSTM1 and MAP2K5
  • important role for the Rho GTPase/PRKCZ/transforming growth factor beta-activated kinase 1/NF-kappaB pathway in host defense and in proinflammatory cytokine synthesis induced by bacterial LPS
    • INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • Zn2+
  • ATP
    • protein
  • SLC39A1
  • SLC39A2
  • KCNAB2
  • PARD6A
  • PARD6B
  • PARD6G
  • SQSTM1
  • CENTA1
  • IKBKB
  • interacting with PRKCQ and PRKCI
  • associates functionally with RHOA and acts as a signaling component downstream of RHOA
  • PRKCZ binds and phosphorylates MAPK7, thereby decreasing NOS3 protein stability and contributing to early events of atherosclerosis
  • EYA1 phosphatase functions through PRKCZ-NOTCH1 signaling to control cell polarity in the lung epithelium
  • represses the expression of PHGDH and PSAT1, and phosphorylates PHGDH at key residues to inhibit its enzymatic activity
  • in response to mechanical stretch, APPL1 enhances glucose uptake by modulating the activation and localization of PRKCZ, as well as its functional interaction with both PPP2CA and MYO2A
    • cell & other
  • diacylglycerol
    • REGULATION
    activated by slightly enhanced by arachidonic acid
    diacylglycerol
    phosphatidylinositol 3,4,5-trisphosphate
    Other regulated by ECT2 and PARD6A
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    may constitute potential therapeutic targets for inflammatory joint diseases involving increased collagenase expression
    ANIMAL & CELL MODELS
    target dysruption of PKCZ in mice results in impair of the NF Kappa B pathway