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FLASH GENE

Symbol

PLK3

contributors: mct - updated : 08-10-2018

HGNC name	polo-like kinase 3
HGNC id	2154

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	polo box duplicated region
	two polo box domains, a conserved Polo-box domain, shown to bind to phosphorylated Ser-pSer/pThr-Pro motifs

conjugated

PhosphoP

HOMOLOGY

interspecies	homolog to yeast S.cerevisiae cdc25p
	ortholog to Drosophila melanogaster polo

Homologene

FAMILY	protein kinase superfamily
	Ser/Thr protein kinase family
	CDC5/Polo subfamily

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
	intracellular,nuclear envelope
text	nuclear membrane at interphase, spindle poles and mitotic spindles throughout mitosis, midbody at telophase

basic FUNCTION	serine/threonine protein kinase involved in regulating M phase functions
	stress response protein that becomes phosphorylated following DNA damage or mitotic spindle disruption
	may regulate entry into S phase in part through interaction with the phosphatase CDC25A, because its depletion also resulted in attenuation of cyclin E expression
	its activation might cause cytoskeleton re-organization and result in growth suppression more pronouncedly in Ras pathway-activated cells
	functions as an important regulator for cell proliferation and it suppresses tumorigenesis
	new and essential player in the regulation of the hypoxia signaling pathway
	essential component in the regulatory network of cell survival, angiogenesis, and hypoxic responses

CELLULAR PROCESS	cell cycle, division, mitosis
	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

text	regulating the onset and/or progression of mitosis
	dysregulated expression results in cell arrest and apoptosis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	regulating the dissociation of cohesin from chromosome in prophase
	interacting with CIB1
	topoisomerase IIalpha (TOP2A) is a novel physiological substrate for PLK3 and that PLK1 and PLK3 play different roles in cell-cycle regulation
	is a negative regulator of HIF-1A stability
	CIB1 is involved in regulating endomitosis, perhaps through its interaction with PLK3

cell & other

REGULATION

induced by

hypoxic stress (hypoxia/reoxygenation induces PLK3 activation instead of the JNK effect to directly phosphorylate and activate JUN, subsequently contributing to apoptosis in corneal epithelial cells)

Other	cell cycle regulated,peak at S and G2 stages through perturbation of microtubule integrety
	regulated by TTP(tristetraprolin) (regulation of PLK3 mRNA stability by TTP may influence the control of the cell cycle by this protein kinase)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in synovial sarcoma after SYT-SSX inhibition

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

PLK3-/- mice develop tumors in multiple organs at an enhanced rate