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FLASH GENE

Symbol

EIF2S1

contributors: mct - updated : 28-12-2016

HGNC name	eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
HGNC id	3265

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --other   elevated phosphorylation of EIF2S1 has been observed in the brains of Alzheimer disease patients constitutional     --over   UPR activation and/or increased EIF2S1 levels are seen in patients with AD, PD and prion disease

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology infectious   promoting EIF2S1 dephosphorylation rescues vital translation rates and is thereby neuroprotective in prion disease

ANIMAL & CELL MODELS

reducing Eif2s1 levels in prion-diseased mice significantly increases survival