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FLASH GENE
Symbol TACSTD2 contributors: mct/shn - updated : 21-06-2023
HGNC name tumor-associated calcium signal transducer 2
HGNC id 11530
Corresponding disease
GDLD gelatinous drop-like corneal dystrophy
Location 1p32.1      Physical location : 59.041.096 - 59.043.166
Genatlas name pancreatic carcinoma marker protein GA7331
Synonym name
  • epithelial glycoprotein-1
  • membrane component, chromosome 1, surface marker 1
  • pancreatic carcinoma marker protein GA733-1
  • pancreatic carcinoma marker protein GA7331
  • cell surface glycoprotein Trop-2
  • cell surface glycoprotein TROP2
  • 40kD glycoprotein, identified by monoclonal antibody GA733
  • gastrointestinal tumor-associated antigen GA7331
  • trophoblast cell surface antigen 2
  • Synonym symbol(s) CAA1, M1S1, EGP1, TROP2, GA773, GA733-1, GDLD , TTD2
    DNA
    TYPE like-sequence
    SPECIAL FEATURE
    text intronless
    STRUCTURE 2.07 kb     1 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence
    text structure intronless
    MAPPING cloned Y linked   status confirmed
    Map pter - D1S405 - D1S2648 - TACSTD2 - D1S2752 - D1S2700 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2080 35 323 - 1999 10192395
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas    
    Reproductivefemale systemovary  highly
     male systemprostate  highly
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidney    
    Visualeyeanterior segmentcornea  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningepidermisstratum basale 
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage normal trophoblast cells
    cell lines carcinoma cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text trophoblast, placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a single transmembrane domain
  • EGF-like and thyroglobulin repeats
  • four potential N-linked glycosylation sites
  • a phosphatidylinositol binding site
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to Tacstd2, Mus musculus
    ortholog to Tacstd2, Rattus norvegicus
    ortholog to TACSTD2, Pan troglodytes
    intraspecies homolog to GA733.2
    Homologene
    FAMILY thyroglobulin type-1 family
    CATEGORY adhesion , tumor suppressor , signaling
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • may play a role in regulating the growth of carcinoma cells (
  • carcinoma associated antigen
  • transducing an intracellular calcium signal and acting as a cell surface receptor
  • functioning as a cell/cell adhesion receptor in cancer cells and as a calcium signal transducer
  • its expression is necessary for tumorigenesis and invasiveness of colon cancer cells
  • activating a molecular signaling pathway which has important implications for cancer cell growth and survival
  • its upregulation quantitatively stimulates human cancer growth
  • is a transmembrane signal transducer that can induce cancer growth
  • TACSTD2 was able to compensate for the loss of EPCAM in stabilizing CLDN7 expression and cell membrane localization in tissues that co-express both proteins
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction , sensory transduction/vision
    calcium signal tranducer
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • non-structural 5A, NS5A
  • binding of LGALS3 to MUC1 enhances likely the recruitment of SP1, leading to promotion of the transcription of TACSTD2
  • TACSTD2 cleavage by ADAM10 is an activator switch for cancer growth and metastasis
  • can tightly interact with ADAM10
  • TACSTD2 was able to compensate for the loss of EPCAM in stabilizing CLDN7 expression and cell membrane localization in tissues that co-express both proteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GDLD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with CCND1 and overexpressed in cancer cells
    tumoral     --over  
    in epithelial ovarian cancer
    tumoral     --over  
    correlates with poor prognosis in pancreatic cancer (
    constitutional     --over  
    may represent a mechanism to maintain/restore epithelial barrier function and contribute to regeneration process in infected/damaged lungs
    tumoral     --over  
    are predictive of recurrence of localized prostate cancer, castration-resistant prostate cancer (CRPC), or neuroendocrine prostate cancer (NEPC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could be a novel prognostic biomarker for pancreatic cancer (
  • could be used as a marker for pathological grading of squamous cell carcinoma (SCC)
  • TACSTD2 may be a valuable prognosis predictive biomarker in human solid tumors
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    targeting of its overexpression by immunotherapeutic strategies may represent an attractive and potentially effective approach in patients harbouring epithelial ovarian cancer
    cancerendocrinepancreas
    might be a useful treatment approach for patients with pancreatic cancer overexpressing this cell-surface marker
    cancer  
    oncogene that has potential as a therapeutic target, and having a restricted expression in normal tissue, anti-Trop-2 therapeutics would be predicted to have limited toxicity
    cancerreproductiveprostate
    is a driver and therapeutic target for metastatic prostate cancer with neuroendocrine phenotype
    cancerdigestivecolon
    is a target in metastatic colon cancer
    cancer  
    potential therapeutic target in human solid tumors
    ANIMAL & CELL MODELS