Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

HSPD1

contributors: mct - updated : 28-03-2020

HGNC name	heat shock 60kDa protein 1 (chaperonin)
HGNC id	5261

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SPG13 , PMLD2

related resource

MITOP database

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in ovarian cancer, pancreatic cancer, large bowel carcinoma (Tsai 2008) tumoral     --low   in clear cell renal cell carcinoma (ccRCC) (pMID: 31112866) tumoral     --low   in hepatocellular carcinoma tissues compared to peritumor tissues tumoral     --over   in glioblastoma patients

Susceptibility

to sudden infant death syndrome (SIDS)

Variant & Polymorphism SNP	pathogenic variant of rs72466451 may play a role in a subgroup of SIDS cases with impaired HSPD1-mediated stress response

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive liver might serve as a potential therapeutic target in the treatment of HCC cancer brain glioma/neuroblstoma is a potential therapeutic target for glioblastoma treatment

ANIMAL & CELL MODELS