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FLASH GENE
Symbol HNRNPF contributors: mct - updated : 19-10-2016
HGNC name heterogeneous nuclear ribonucleoprotein F
HGNC id 5039
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
three RNP-like (qRRM) motifs
conjugated RiboP
HOMOLOGY
intraspecies homolog to HNRNPH2
Homologene
FAMILY HNRP family
CATEGORY RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport
  • is involved in the regulation of mRNA metabolism by specifically recognizing G-tract RNA sequences
  • would act by remodeling RNA secondary and tertiary structures
  • is a regulatory element of MBP expression in oligodendrocytes, suggesting an important function of HNRNPF in the control of myelin synthesis
  • plays a modulatory role and can ameliorate hypertension, renal hypertrophy, and interstitial fibrosis in diabetes
  • HNRNPH2/HNRNPF regulate genes that are involved in the transition from oligodendrocyte progenitor cells to oligodendrocytes
  • HNRNPF stimulates ACE2 gene transcription, prevents TGFB1 inhibition of ACE2 gene transcription and induction of kidney injury in diabetes
  • HNRNPH2, and HNRNPF have each been identified in neurons and are important in cellular proliferation, differentiation, and apoptosis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of heterogeneous nuclear RNA ribonucleoprotein complex
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • developmental changes in HNRNPH2/HNRNPF associated with oligodendrocytes (OLs) differentiation synergistically regulate PLP1 alternative splicing and a G-rich enhancer participates in the regulation
  • HNRNPH2 and HNRNPF regulate PLP1 splicing by recruiting U1snRNP and HNRNPH2 plays a primary role in PLP1 splice site selection
  • specific interaction between MTOR and RPS6K2 with HNRNPF is implicated in the regulation of cell proliferation
  • RNA-binding protein HNRNPF is a novel component of MBP mRNA transport granules
  • HNRNPF directs formation of the exon 4 minus variant of ENOX2
  • HNRNPA1 and HNRNPF modulate the alternative splicing of exon 11 of the insulin receptor gene
  • is a co-factor in a subset of ZFP36/BRF1-mediated mRNA decay
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabete  
    may be potential targets in the treatment of hypertension and kidney injury in diabetes
    ANIMAL & CELL MODELS
  • insulin prevents hypertension and attenuates kidney injury, at least in part, through suppressing renal Agt transcription via upregulation of hnRNP F and hnRNP K expression in diabetic Akita mice