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FLASH GENE

Symbol

HNRNPF

contributors: mct - updated : 19-10-2016

HGNC name	heterogeneous nuclear ribonucleoprotein F
HGNC id	5039

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	23.63 kb     6 Exon(s)

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001098204 4 - 2650 NP_001091674 - 415 - 2011 21625959 NM_004966 4 - 2651 NP_004957 - 415 - 2011 21625959 NM_001098205 4 - 2690 NP_001091675 - 415 - 2011 21625959 NM_001098206 4 - 2657 NP_001091676 - 415 - 2011 21625959 NM_001098207 4 - 2694 NP_001091677 - 415 - 2011 21625959 NM_001098208 3 - 2773 NP_001091678 - 415 - 2011 21625959

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Endocrine pancreas         Lymphoid/Immune thymus         Nervous brain         Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

three RNP-like (qRRM) motifs

conjugated

RiboP

HOMOLOGY

intraspecies

homolog to HNRNPH2

Homologene

FAMILY

HNRP family

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm

basic FUNCTION	associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport
	is involved in the regulation of mRNA metabolism by specifically recognizing G-tract RNA sequences
	would act by remodeling RNA secondary and tertiary structures
	is a regulatory element of MBP expression in oligodendrocytes, suggesting an important function of HNRNPF in the control of myelin synthesis
	plays a modulatory role and can ameliorate hypertension, renal hypertrophy, and interstitial fibrosis in diabetes
	HNRNPH2/HNRNPF regulate genes that are involved in the transition from oligodendrocyte progenitor cells to oligodendrocytes
	HNRNPF stimulates ACE2 gene transcription, prevents TGFB1 inhibition of ACE2 gene transcription and induction of kidney injury in diabetes
	HNRNPH2, and HNRNPF have each been identified in neurons and are important in cellular proliferation, differentiation, and apoptosis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of heterogeneous nuclear RNA ribonucleoprotein complex

INTERACTION

DNA

RNA

binding

small molecule

protein	developmental changes in HNRNPH2/HNRNPF associated with oligodendrocytes (OLs) differentiation synergistically regulate PLP1 alternative splicing and a G-rich enhancer participates in the regulation
	HNRNPH2 and HNRNPF regulate PLP1 splicing by recruiting U1snRNP and HNRNPH2 plays a primary role in PLP1 splice site selection
	specific interaction between MTOR and RPS6K2 with HNRNPF is implicated in the regulation of cell proliferation
	RNA-binding protein HNRNPF is a novel component of MBP mRNA transport granules
	HNRNPF directs formation of the exon 4 minus variant of ENOX2
	HNRNPA1 and HNRNPF modulate the alternative splicing of exon 11 of the insulin receptor gene
	is a co-factor in a subset of ZFP36/BRF1-mediated mRNA decay

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed diabete     may be potential targets in the treatment of hypertension and kidney injury in diabetes

ANIMAL & CELL MODELS

insulin prevents hypertension and attenuates kidney injury, at least in part, through suppressing renal Agt transcription via upregulation of hnRNP F and hnRNP K expression in diabetic Akita mice