motifs/domains
| N-terminal PB1 domain, needed for homo-polymerization, and MAPK14 interaction (NPI) domain, |
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a zinc-finger cysteine-rich region |
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a potential 6 protein binding domain |
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a PEST motif and several phosphorylation sites |
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a SH2 domain |
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two clusters of positively charged AAs resembling the basic monopartite nuclear localization signal (AAs 186–189 (NLS1) and AAs 264–267 (NLS2)  |
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C-terminal UBA domain, and MAPK14 interaction (CPI) domain |
| basic FUNCTION
| immediate-early response gene that responds to a variety of extracellular signals involved in proliferation, differentiation and particularly oxidative stress |
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potentially involved in the regulation of fate of ubiquinated proteins by segregation (formation) |
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functioning in multiple signal transduction pathways activated by receptor activator of NFKB ligand (RANKL), tumor necrosis factor (TNF-alpha) and IL-1, that promote osteoclast (OCL) formation at least in part through NFKB activation |
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functions as a scaffold protein to integrate and diversify signals from multiple receptors, including tumour necrosis factor receptor family members, interleukin receptors, and nerve growth factor receptors |
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critical role in cytokine-dependent MAPK14 signalling pathway |
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ubiquitin-binding adaptor or scaffold protein implicated in many cellular functions |
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proteotoxic stress response protein, that may act as a ubiquitin chain-targeting factor shuttling substrates for proteasomal degradation |
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play fundamental roles in the control of bone remodeling through the regulation of signaling pathways in different cell types |
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SQSTM1 and CALCOCO2 act cooperatively to drive efficient antibacterial autophagy by targeting the protein complexes they coordinate to distinct micro-domains associated with bacteria |
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DRAM1 and SQSTM1 regulate cell motility and invasion in GBM stem cells |
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novel function of the autophagy regulators DRAM1 and SQSTM1 in control of migration/invasion in cancer stem cells |
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controls thermogenesis in a cell-autonomous manner, independently of brown adipocyte development or differentiation and is a novel regulator of mitochondrial function and brown fat thermogenesis |
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is a critical regulator of the hypoxia response and EGLN3 activity, by inducing EGLN3 aggregation and degradation under normoxia |
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SQSTM1 is decreased through autophagy-mediated degradation, while ELAVL1 through the proteasomal pathway |
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plays a key role in regulating the recruitment of F-actin network assemblies to the microtubule organizing center (MTOC), a critical cellular function that is required for successful autophagic clearance of protein aggregates (PMIDS: |
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implicated as an adaptor protein to mediate autophagic clearance of insoluble protein aggregates in age-related diseases, including age-related macular degeneration (AMD) |
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SQSTM1 and autophagy synergize to promote tumor growth, suggesting that inhibition of both pathways could be more effective than targeting either alone for cancer therapy |
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plays a critical role in recognizing/loading cargo (e.g., malfolded proteins) into autophagosomes for lysosomal degradation |
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PINK1, PARK2 and SQSTM1 have been shown to regulate mitophagy, leaving hitherto ill-defined the contribution by key players in 'general' autophagy |
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SQSTM1 is a critical regulator in CD40-mediated NFKB1 signaling via TRAF6 |
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multidomain scaffolding protein involved in various key cellular processes, including the removal of damaged mitochondria by its function as a selective autophagy receptor |
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in dividing cells, contributes to the early regulation of mitophagy including perinuclear clustering of mitochondria and autophagosome formation upon depolarization, but it is redundant for mitochondrial removal and autophagic flux |
