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FLASH GENE
Symbol CNOT4 contributors: mct/npt - updated : 22-05-2010
HGNC name CCR4-NOT transcription complex, subunit 4
HGNC id 7880
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • RNA recognition motif
  • N terminal domain with two putative zinc fngers of the C4C4 type (RING finger) that acts as an E3 ubiquitin ligase and specifically interacts with UBE2D2, a ubiquitin-conjugating enzyme
  • C terminal bipartite nuclear localization signal (NLS)
    • HOMOLOGY
    interspecies homolog to C.elegans C49h3.5
    ortholog to yeast S.cerevisiae Ccr4-Not
    Homologene
    FAMILY
    CATEGORY enzyme , regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • functions as an E3 ligase by modulating UBE2D2-mediated stress responses (Mulder 2007)
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the CCR4-NOT (CAF1) complex involved in the control of gene expression
  • CNOT4 complex is evolutionarily conserved and important for regulation of mRNA synthesis and decay (Lau 2009)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CNOTs proteins
  • interacting with NANOS2, a deadenylation complex , which can cleave poly(A) RNA (Suzuki 2010)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS