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FLASH GENE

Symbol

TMX1

contributors: npt/mct - updated : 04-11-2015

HGNC name	thioredoxin domain containing 1
HGNC id	15487

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	14q22.1      Physical location : 51.706.885 - 51.724.370
Synonym name	thioredoxin-related transmembrane protein
	Trx-related protein
	thioredoxin domain containing
Synonym symbol(s)	TMX, TXNDC, DKFZP564E1962, UNQ235/PRO268, TXNDC1

DNA

TYPE	functioning gene
STRUCTURE	17.49 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_030755 8 - 4119 31 280 - Matsuo (2009)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly Digestive liver       moderately Endocrine pancreas       highly Nervous brain       moderately Reproductive male system prostate     highly Respiratory lung       moderately Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone       Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid         Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal signal peptide containing the Trx-like domain present with a catalytic CXXC motif in the ER lumen, where protein disulfide isomerase (PDI) was found to assist protein folding
	a thioredoxin (TRX)-like domain with a unique active site sequence Cys-Pro-Ala-Cys, with oxidoreductase activity
	ER-targeting signal sequence
	one transmembrane domain (Sugiura 2010)

HOMOLOGY

interspecies

homolog to C.elegans F54d8.3

Homologene

FAMILY

thioredoxin family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
text	as CANX, shuttles between the rough ER and the shuttles between the rough ER and the mitochondria-associated membrane (MAM) depending on its palmitoylation status

basic FUNCTION	can modify certain molecules with its oxidoreductase activity and be involved in the redox regulation in the ER
	specific role for TMX1 and its mechanism of action in redox-based ER quality control (Matsuo 2009)
	prevents an overexpressed major histocompatibility complex class I heavy chain from being degraded (Sugiura 2010)
	cooperate with calnexin in protein retention in the ER, followed by refolding of misfolded proteins (Sugiura 2010)
	thought to be an isomerase in the ER (Sugiura 2010)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

energetic

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

associates with the molecular chaperon calnexin, which can mediate substrate binding (Matsuo 2009)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS