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| Gm3-deficient jck mice displayed milder PKD, revealing a pivotal role for ganglioside GM3, and loss of GM3 synthase gene, is protective against murine nephronophthisis-related polycystic kidney disease (PMID;  | |
defect of hearing ability of St3gal5 null mice could be attributed to the functional disorganization of the organ of Corti, and the expression of gangliosides, especially GM3, during the early part of the functional maturation of the cochlea could be essential for the acquisition and maintenance of hearing function |