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FLASH GENE

Symbol

ST6GALNAC5

contributors: mct - updated : 11-10-2010

HGNC name	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
HGNC id	19342

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in cervical cancer tumoral     --over   in tumorigenic, glioma cells, leading to enhanced phosphorylation of HSPA8/HSC70 in response to attachment to fibronectin, intimately involved in tumor cell adhesion, motility, and invasion

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	modulation of the synthesis of specific glioma cell-surface glycosphingolipids alters invasivity in a manner that may have significant therapeutic potential

ANIMAL & CELL MODELS