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FLASH GENE

Symbol

ADCK3

contributors: mct - updated : 02-05-2013

HGNC name	aarF domain-containing protein kinase 3
HGNC id	16812

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal kinase motifs
	an ABC1-like motif

HOMOLOGY

interspecies	ortholog to yeast S.pombe ABC1 family (unrelated to ABC transporter)
	homolog to yeast Coq8p

Homologene

FAMILY

CATEGORY

chaperone/stress

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria

basic FUNCTION	potentially mediating TP53-inducible apoptosis through the mitochondrial pathway
	having a protein kinase function in Q biosynthesis

CELLULAR PROCESS	cell life, proliferation/growth
	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

text	supressor of cell growth inducer of apoptosis

PATHWAY

metabolism

signaling

part of the CoQ(10) biosynthetic pathways with PDSS1, PDSS2, COQ2, COQ6, COQ9

a component

INTERACTION

DNA

RNA

small molecule

protein

target of the TP53 tumor suppressor (third TP53-regulated gene in mitochondrial disorders)

cell & other

REGULATION

induced by

the tumor suppressor TP53 and in response to DNA damage

ASSOCIATED DISORDERS

corresponding disease(s)

UDCA

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS