SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,chromatin/chromosome,kinetochore
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| text
| centriolar |
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associated to centrosome (connected to its role in neuronal migration, since the centrosome is believed to aid nuclear movement (nucleokinesis) as neurons move to its final destination in the cortex) |
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dynamically colocalizes with cytoplasmic dynein at centrosome, mitotic spindles, kinetochores, and cell cortex to execute various biological processes |
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colocalizes with cytoplasmic dynein and dynactin, predominantly in prometaphase kinetochores and at the cell cortex of dividing cells |
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in cytoplasm, localized to two punctate structures, one of which was located near the base of the flagella |
| basic FUNCTION
| implicated in brain development, acts in several processes mediated by the dynein/dynactin pathway by interacting with dynein and other proteins |
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component of overlapping but distinct signal pathways including DCX that promotes neuronal migration |
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required for ordered neuronal migration in the cortex |
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playing a role in nuclear migration by interacting with multiple intracellular proteins and regulating cytoplasmic dynein function |
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playing a specific roles, with cytoplasmic dynein in radial migration and accumulate at the leading cell cortex of migrating fibroblasts |
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participates in a subset of dynein functions and may regulate the division of neuronal progenitor cells in the developing brain |
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regulating cytoplasmic dynein, as the motor responsible for centrosomal movement in neural precursor cells |
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playing an essential role for precise control of mitotic spindle orientation in both neuroepithelial stem cells and radial glial progenitor cells |
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function in microtubule capture and stabilization (may play a broader role throughout neural development in neuronal migration, neurite extension, and neuronal survival, besides its role neuroepithelial expansion and radial glial neurogenesis) |
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implicated in neuronal and non-neuronal migration and axon formation |
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suppresses the motility of cytoplasmic dynein on microtubules |
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mediating anterograde transport of cytoplasmic dynein to the plus end of cytoskeletal microtubules (MTs) as a dynein–PAFAH1B1 complex on transportable MTs |
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have important functions in the major migratory pathway in the developing forebrain |
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antagonistic effect of PAFAH1B2, PAFAH1B3 and NDEL1 for PAFAH1B1 binding, probably to modulate dynein functions |
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serves as a key regulator of the cytoplasmic dynein complex |
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inducing with NDE1 a persistent-force dynein state |
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functions as an intrinsic factor to control germline stem cell self-renewal, at least in part through regulating BMP signal transduction and E-cadherin–mediated cell adhesion |
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plays a potential tumor suppressor role in the development and progression of hepatocellular carcinoma |
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PAFAH Ib regulates endocytic membrane trafficking through novel mechanisms involving both PLA(2) activity and PAFAH1B1-dependent dynein function |
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important partner of the dynein/dynactin complex that plays several roles in the mitosis |
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essential for cortical microtubule organization and desmosome stability in the epidermis |
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association of PAFAH1B1 with outer arm dynein is modulated in response to alterations in flagellar motility |
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specific but cell type-restricted role for PAFAH1B1 in large vesicular transport |
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association of P with outer arm dynein is modulated in response to alterations in flagellar motility |
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has likely a general role in initiating dynein-driven motility |
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operates like a “clutch” that prevents dynein's ATPase domain from transmitting a detachment signal to its track-binding domain |
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can convert dynein to a mechanochemical state in which its velocity is slowed and its microtubule attachments are prolonged |
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can generate mechanical diversity by regulating the structural changes that propagate through dynein's large motor domain |
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NDEL1, NUDCD3, PAFAH1B1 are critical components of cytoplasmic dynein complex |
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novel roles of PAFAH1B1, NDEL1 and NUDCD3 in the transport of mitochondria in axons |
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NDEL/NDE1 and PAFAH1B1 promote dynein and dynactin interaction in the context of spindle morphogenesis |
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WDR47 shares functional characteristics with PAFAH1B1 and participates in key microtubule-mediated processes, including neural stem cell proliferation, radial migration, and growth cone dynamics |
