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FLASH GENE
Symbol STH contributors: mct - updated : 10-07-2013
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION
  • possible contribution of STH gene products on the heterogeneity of core frontal executive functions deterioration, probably through complex interactions with mechanism involved in neurodevelopment and neurodegeneration
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with peroxiredoxin 6 (PRDX6), a unique member of that family that is bifunctional and the levels of which increase in Pick disease
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to late onset Alzheimer's disease
  • several tauopathies(frontotemporal dementia )
    • Variant & Polymorphism SNP
  • Q7R overexpressed in late onset Alzheimer's disease
  • QQ genotype associated with frontotemporal dementia
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS