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FLASH GENE

Symbol

STH

contributors: mct - updated : 10-07-2013

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q21.31      Physical location : 790.688 - 44.077.060
Genatlas name	saitohin
Synonym symbol(s)	MAPTIT

DNA

TYPE	functioning gene
SPECIAL FEATURE	overlapping, gene in gene
text	in intron 9 of gene MAPT
STRUCTURE	0.44 kb     1 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001007532 1 - 445 NP_001007533 - 128 - -

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly   brain hindbrain cerebellum

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central

cell lineage
cell lines	oligodendroglioma cell lines
fluid/secretion

at STAGE

physiological period

pregnancy

Text	placenta, brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION

possible contribution of STH gene products on the heterogeneity of core frontal executive functions deterioration, probably through complex interactions with mechanism involved in neurodevelopment and neurodegeneration

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacts with peroxiredoxin 6 (PRDX6), a unique member of that family that is bifunctional and the levels of which increase in Pick disease

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to late onset Alzheimer's disease several tauopathies(frontotemporal dementia )

Variant & Polymorphism SNP	Q7R overexpressed in late onset Alzheimer's disease
	QQ genotype associated with frontotemporal dementia

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS