| basic FUNCTION
| ubiquitin-protein isopeptide ligase, required for NF kappa B activation and IL-8 gene expression in response to IL-1, probably through its signal-dependent interaction with IRAK4, IRAK, TRAF6 |
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implicated as evolutionary conserved scaffold proteins in TLR/IL-1R signaling leading to nuclear factor-kappaB and mitogen activated protein kinase-dependent gene expression |
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E3 ligases that can catalyze Lys(63)-linked polyubiquitination but also shows bidirectional signaling between the IRAK and Pellino families and highlights a novel function for IRAK kinase activity |
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RING E3 ubiquitin ligases involved in signaling events downstream of the Toll and interleukin-1 (IL1) receptors, key initiators of innate immune and inflammatory responses  |
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induce IRAK1 polyubiquitination in a RING-dependent manner |
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PELI1 and PELI2 appear to function as positive regulators for NFKB activation |
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ubiquitin ligase needed for the transmission of TICAM1-dependent TLR signals |
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PELI1, PELI2, PELI3 are novel RING E3 ubiquitin ligases involved in IRAK1 polyubiquitination and degradation |
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PELI2, PELI3 (to a much lesser degree Pellino 1) carry the E3 ubiquitin ligase activity and promote polyubiquitination on IRAK1 |
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Pellino1 is a novel component of the signal transduction network by which viral double-stranded RNA stimulates IFNB1 gene transcription |
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PELI1 interacts with the transcription factor DEAF1, and this interaction is independent of the E3 ligase activity of PELI1, but weakened by the phosphorylation of PELI1 |
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PELI1, PELI2, PELI3 E3 ubiquitin ligases are emerging as critical mediators for a variety of immune signaling pathways, including those activated by Toll-like receptors, the T-cell receptor, and NOD2 |
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nonredundant roles that PELI1, PELI2, PELI3 play in immune signaling are in part due to their divergent substrate specificities |
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promotes lymphomagenesis by deregulating BCL6 polyubiquitination |
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previously unrecognized role of PELI1 in extracellular matrix deposition and cardiac fibroblast activation in response to mechanical stress |
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is an innate immune regulator in the CNS that modulates the threshold of IFN1 responses against viral infections |
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play a pivotal role in inflammatory processes through the activation of Toll-like receptor signaling and the NFKB1 pathway |
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might participate in B-cell maturation or oncogenic activation of aggressive B-cell lymphomas, both during and after germinal center stages |
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PELI1 is a key modulator of RIPK1 that differentially controls the activation of necroptosis and apoptosis |
