motifs/domains
| two fibronectin type III domain |
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>68 immunoglobulin domains |
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pleckstrin homology domain |
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two serine/threonine kinase domains |
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one calcium/calmodulin binding domain |
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several interacting modules, one of which mediates binding to muscle-specific ankyrins  |
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a C terminal Rho GEF domain, with two distinct binding sites to mediate binding with ANK1I5 and ANK1I9, rhoGEF domain and tandem pleckstrin homology domain, are consistent with a role in rho signaling in muscle |
| basic FUNCTION
| giant muscle protein involved in Ca2+/calmodulin and G protein-couples signal transduction in the sarcomere |
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having important functions in cardiac and skeletal muscle physiology |
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C-terminal region interacts with sarcomeric myosin and may play a critical role in its ability to assemble into A bands in striated muscle |
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play several distinct roles in organizing and stabilizing the contractile apparatus and nearby structures |
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playing a role in mediating the subcellular localization of small ANK1 isoforms in striated muscle cells |
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multidomain protein composed of adhesion and signaling domains that plays key roles in the organization of contractile and membrane structures in striated muscles |
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modular protein of striated muscle that concentrates around the M-bands and Z-disks of each sarcomere, where it is well positioned to sense contractile activity |
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its rhoGEF domain signals at least in part by inducing RHOA expression and activation, and altering the expression of downstream kinases in skeletal muscle |
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OBSCN and KCTD6 regulate cullin-dependent small ankyrin-1 (ANK1) protein turnover |
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play essential roles in myofibrillogenesis, cytoskeletal organization, and Ca(2+) homeostasis |
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may play common and unique roles, respectively, in the regulation and maintenance of cell homeostasis in various tissues and organs throughout the body |
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giant cytoskeletal protein with structural and regulatory roles |
