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FLASH GENE
Symbol PLSCR4 contributors: mct - updated : 10-12-2010
HGNC name phospholipid scramblase 4
HGNC id 16497
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • multiple PXXP motifs
  • a PPXY motif located near the N terminus implying the potential for interaction with SH3 or WW domain-containing proteins
  • a Ca2+ binding motif that is a novel type of Ca2+ binding motif
    • conjugated LipoP , Other
    HOMOLOGY
    Homologene
    FAMILY
  • phospholipid scramblase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II membrane protein
    basic FUNCTION
  • mediating calcium dependent bidirectional movement between membrane bilayers in adjured, activated, or apoptotic cells
  • may play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in recognition of apoptotic and injured cells by the reticuloendothelial system
  • facilitate the translocation of aminophospholipids from the inner to the exterior leaf of the cell membrane
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • with PLSCR1, interact directly with the CD4 receptor at the cell surface of T lymphocytes
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS