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FLASH GENE

Symbol

PLSCR4

contributors: mct - updated : 10-12-2010

HGNC name	phospholipid scramblase 4
HGNC id	16497

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	clustered with PLSCR1 and PLSCR2
STRUCTURE	58.84 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001177304 6 - 3014 NP_001170775 - 224 - - NM_001128306 7 - 3042 NP_001121778 36.9 239 - 2000 10930526 NM_020353 9 - 3312 NP_065086 36.9 329 - 2000 10930526

EXPRESSION

Type

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen           thymus         Cardiovascular heart         Digestive intestine small intestine         intestine large intestine colon       liver         Endocrine pancreas         Nervous brain         Reproductive female system uterus       Homo sapiens   male system testis         male system prostate       Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	multiple PXXP motifs
	a PPXY motif located near the N terminus implying the potential for interaction with SH3 or WW domain-containing proteins
	a Ca2+ binding motif that is a novel type of Ca2+ binding motif

conjugated

LipoP , Other

HOMOLOGY

Homologene

FAMILY

phospholipid scramblase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
text	type II membrane protein

basic FUNCTION	mediating calcium dependent bidirectional movement between membrane bilayers in adjured, activated, or apoptotic cells
	may play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in recognition of apoptotic and injured cells by the reticuloendothelial system
	facilitate the translocation of aminophospholipids from the inner to the exterior leaf of the cell membrane

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein

with PLSCR1, interact directly with the CD4 receptor at the cell surface of T lymphocytes

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS