Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

CYGB

contributors: mct - updated : 11-01-2015

HGNC name	cytoglobin
HGNC id	16505

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral         in oesophageal biopsies from tylotic patients (TOC) constitutional     --over   under hypoxic and/or ischemic conditions increases cell survival, suggesting possible protective roles through prevention of oxidative damage tumoral     --over   hypoxic up-regulation of CYGB/NGB in glioblastoma multiforme cell lines and tumor tissues tumoral     --low   in breast cancer tissues and cell lines, which was associated with promoter methylation

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurosensorial visual retina should be considered when developing therapeutic strategies for treatment of hypoxia-related ocular diseases cancer brain glioma/neuroblstoma modulating cytoglobin levels may be a promising treatment strategy for sensitizing human glioma cells to oxidative stress that is induced by ionizing radiation, certain chemotherapies and ischemia-reperfusion. miscelleaneous urinary chronic kidney disease might represent a good therapeutic target in chronic kidney disease

ANIMAL & CELL MODELS