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FLASH GENE

Symbol

KIF15

contributors: mct - updated : 27-04-2020

HGNC name	kinesin family member 15
HGNC id	17273

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020242 35 - 4760 NP_064627 - 1388 - 2019 30797758

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver           salivary gland         Hearing/Equilibrium ear inner cochlea     Nervous brain         Homo sapiens   nerve cranial nerve       Reproductive male system prostate       Respiratory lung         Urinary kidney

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one myosin tail
	a kinesin motor domain

mono polymer

heteromer , oligo

HOMOLOGY

interspecies	homolog to murine Kif15 (86.2pc)
	homolog to rattus Kif15 (85.2pc)

Homologene

FAMILY

kinesin-like protein family

CATEGORY

motor/contractile , DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle

basic FUNCTION	may be involved in control of cell proliferation
	similar to KIF11, KIF15 can drive centrosome separation during bipolar spindle assembly
	mitotic motor protein that continues to be expressed in developing neurons
	mitotic microtubule-associated motor protein, impacting axonal growth, navigation, and branching
	acts predominantly on kinetochore fibers to regulate their lengths
	KIF15 bound to kinetochore fibers antagonizes centrosome separation while KIF15 bound to nonkinetochore MTs mediates centrosome separation
	KIF11, KIF15, and dynein work together to build a bipolar spindle and reveal an important role for antagonistic motors in chromosome segregation
	plays a crucial role in assembly and maintenance of the mitotic spindle
	cooperate to suppress microtubule catastrophes and drive the formation of parallel microtubule bundles
	participates in important events during neuronal development, such as cell division of neuronal precursors, migration of young neurons and establishment of axons and dendritic arbors, by regulating microtubule organization
	both KIF15 and KIFBP are required for the alignment of all the chromosomes to the metaphase plate and the assembly of stable kinetochore fibers of the correct length
	is a critical regulator that promotes pancreatic cancer proliferation
	function in many different cellular processes, including proliferation, apoptosis, differentiation and development
	KIF15 is a microtubule-dependent motor protein involved in multiple cell processes, such as cell division
	could play a critical role in the regulation of cell proliferation of hepatocellular carcinoma (HCC)

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

text	control of cell proliferation

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	nucleotide,
	ATP binding

protein	MKI67 (for the progression of mitosis)
	KIFBP is a specific interaction partner of KIF15 in mitosis, and promotes the localization of KIF15 to the spindle equator close to the chromosomes
	KIFBP reduces the activity of KIF18A and KIF15 during metaphase (directly inhibits KIF18A and KIF15 motor activity by preventing microtubule binding)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function in glioma tumor tissues and positively correlated with pathological staging, recurrence risk and poor prognosis tumoral       gain of function in human pancreatic cancer tissues

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	served as a prognostic indicator for glioma
	may serve as a novel diagnostic target for melanoma, especially uveal melanoma
	higher KIF15 expression levels correlated with shorter patient survival times in pancreatic cancer
Therapy target
	System Type Disorder Pubmed cancer brain glioma/neuroblstoma may be a therapeutic target for glioma therapy cancer digestive liver KIF15 could be a novel therapeutic target for the treatment of hepatocellular carcinoma (HCC) cancer eye   therapeutic target for melanoma, especially uveal melanoma

ANIMAL & CELL MODELS