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FLASH GENE
Symbol CARD9 contributors: mct/ - updated : 16-12-2009
HGNC name caspase recruitment domain family, member 9
HGNC id 16391
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a CARD domain
    • secondary structure six or seven antiparallel alpha helices in the CARD domain
    HOMOLOGY
    interspecies ortholog to rattus Card9
    ortholog to murine Card9
    Homologene
    FAMILY
  • caspase recruitment domain (CARD) family
    • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • activator of BCL10 leading to NFKB activation
  • acting as a postive regulator of apoptosis
  • thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB
  • is a key transducer of Dectin-1 signaling (controlling a non-TLR pathway for innate anti-fungal immunity)
  • required for innate immune responses to intracellular pathogens
  • required for Toll-like receptor-induced activation of dendritic cells through the activation of mitogen-activated protein kinases
  • adaptor protein essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    NFKB signaling
    a component CARD9-BCL10-MALT1 pathway activated by SYK
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BCL10 (CARD domain)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CANDF2
    Susceptibility to Crohn's disease and ulcerative colitis
    Variant & Polymorphism SNP increasing the risk of Crohn's disease and ulcerative colitis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS