Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | CARD9 | contributors: mct/ - updated : 16-12-2009 |
HGNC name | caspase recruitment domain family, member 9 |
HGNC id | 16391 |
|
DNA |
TYPE | functioning gene |
STRUCTURE | 9.73 kb 13 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cells |
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cell lineage
cell lines
| fluid/secretion
| |
at STAGE |
physiological period | pregnancy |
Text | placenta |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
|
secondary structure | six or seven antiparallel alpha helices in the CARD domain |
HOMOLOGY |
interspecies | ortholog to rattus Card9 |
ortholog to murine Card9 |
Homologene |
FAMILY |
CATEGORY | adaptor |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,cytoplasm |
basic FUNCTION | |
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CELLULAR PROCESS | cell life, cell death/apoptosis |
PHYSIOLOGICAL PROCESS | immunity/defense |
PATHWAY |
metabolism |
signaling | signal transduction |
NFKB signaling |
a component | CARD9-BCL10-MALT1 pathway activated by SYK |
INTERACTION |
DNA |
RNA |
small molecule |
protein |
cell & other |
REGULATION |
ASSOCIATED DISORDERS |
corresponding disease(s) | CANDF2 |
Susceptibility | to Crohn's disease and ulcerative colitis |
Variant & Polymorphism SNP | increasing the risk of Crohn's disease and ulcerative colitis |
Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |