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FLASH GENE

Symbol

ST3GAL6

contributors: - updated : 08-09-2005

HGNC name	ST3 beta-galactoside alpha-2,3-sialyltransferase
HGNC id	18080

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune macrophage Skin/Tegument melanocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N-terminal type II transmembrane domain
	two sialyl motifs
	a C-terminal motif
	a large catalytic domain with 297 amino acids

HOMOLOGY

interspecies

ortholog to murine Siat 10

intraspecies	homolog to ST3Gal III
	homolog to ST3Gal IV
	homolog to ST3Gal V

Homologene

FAMILY

glycosyltransferase family 29

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
text	type II membrane protein

basic FUNCTION	playing a role in synthesis of sialyl-paragloboside (precursor of sialyl-Lewis X determinant)
	lipid and protein modification

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

other

signaling

aminosugar metabolism and glycolipid metabolism

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS