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FLASH GENE
Symbol ST3GAL6 contributors: - updated : 08-09-2005
HGNC name ST3 beta-galactoside alpha-2,3-sialyltransferase
HGNC id 18080
Location 3q12.2      Physical location : 98.451.571 - 98.513.234
Synonym name alpha 2,3-sialyltransferase
Synonym symbol(s) ST3GALVI, SIAT10
DNA
TYPE functioning gene
STRUCTURE 61.00 kb     10 Exon(s)
regulatory sequence Promoter
alternative promoter
text structure specifically expressed by atternative promoter utilization and regulated at the level of transcription
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunemacrophage
Skin/Tegumentmelanocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal type II transmembrane domain
  • two sialyl motifs
  • a C-terminal motif
  • a large catalytic domain with 297 amino acids
    • HOMOLOGY
    interspecies ortholog to murine Siat 10
    intraspecies homolog to ST3Gal III
    homolog to ST3Gal IV
    homolog to ST3Gal V
    Homologene
    FAMILY glycosyltransferase family 29
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • type II membrane protein
    • basic FUNCTION
  • playing a role in synthesis of sialyl-paragloboside (precursor of sialyl-Lewis X determinant)
  • lipid and protein modification
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    aminosugar metabolism and glycolipid metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS