SUBCELLULAR LOCALIZATION
| plasma membrane,junction,tight
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| plasma membrane,junction,desmosome
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| intracellular
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| intracellular,cytoplasm,organelle,Golgi
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| text
| integral transmembrane protein of tight junction, colocalizing with F actin at membrane ruffles |
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single-pass type I membrane protein |
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co-localized with TJP1 to adherens-like junctions |
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localizes to the apically localized tight junctions (TJs) between contacting endothelial and epithelial cells, where it contributes to cell-cell adhesions  |
| basic FUNCTION
| mediating interaction of JAM2 with T, NK and dendritic cells |
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may participating in cell-cell adhesion distinct from tight junctions |
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playing an important role in maintaining the integrity and function of myelinated peripheral nerves |
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participating in the later steps of the leukoendothelial adhesion cascade |
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may playing a role in desmosomal structure/function |
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a possible role in endothelial cell polarity |
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required for the differentiation of round spermatids into spermatozoa |
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play an important role in the assembly and maintenance of tight junctions and in the establishment of epithelial cell polarity |
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required for maturation and polarization of cone photoreceptors cells |
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JAM1, JAM2, JAM3 expressions on the lymphatic endothelium may contribute to both seal the cell-cell contact at interendothelial junctions |
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a component of the autotypic junctional attachments of Schwann cells, plays an important role in maintaining the integrity and function of myelinated peripheral nerves |
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regulates unidirectional monocyte transendothelial migration in inflammation |
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important for tight junction formation and polarization of human retinal pigment epithelium cells and promotes the basal-to-apical transmigration of granulocytes through the hfRPE |
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regulate transmigration of granulocytes in retinal pigment epithelium, and it might play a role in retinal inflammatory processes |
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plays a critical role in the initiation of inflammatory pathologies of the retina |
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regulates polarized transendothelial migration of neutrophils |
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is a novel surface marker for neural stem cells |
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JAMB and JAMC are potentially essential for vertebrate myocyte fusion |
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role of JAM2, JAM3 in progression of gastric adenocarcinoma |
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play critical roles during development and in immune responses |
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is involved in germ cell polarity and acrosome formation |
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plays a pivotal role in neutrophil transmigration into tissues |
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may be a novel tumor suppressor gene with epigenetic reduction in colorectal cancer (CRC) |
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dynamic JAM3 trafficking and degradation are necessary for junctional remodelling during cell migration and angiogenesis |
