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FLASH GENE
Symbol PDK3 contributors: npt/ - updated : 05-05-2006
HGNC name pyruvate dehydrogenase kinase, isoenzyme 3
HGNC id 8811
Location Xp22.11      Physical location : 24.483.343 - 24.568.582
Synonym name
  • pyruvate dehydrogenase, lipoamide, kinase isozyme 3, mitochondrial
  • pyruvate dehydrogenase kinase isoform 3
    • EC.number 2.7.11.2
    DNA
    TYPE functioning gene
    STRUCTURE 74.61 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 12795 - 415 - -
    11 - 1803 - 406 - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • histidine-kinase domain
    • HOMOLOGY
    Homologene
    FAMILY
  • PDK/BCKDK protein kinase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • with PDK2 and PDK4 are primary PPARbeta/delta target genes underlining the importance of the receptor in the control of metabolism (Degenhardt 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS